ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the stage or effect of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterized by vasospasm and tissue ischemia has been associated with coadministration of ritonavir Watch Closely (1)pirtobrutinib will increase the